Healthy eating and dietary intervention to promote longevity and prevent age-related diseases

This Collection supports and amplifies research related to SDG 3.

The global population is aging at an unprecedented rate, making the promotion of healthy longevity and prevention of age-related diseases one of the most pressing challenges in biomedical research. Recent advances in nutritional science, aging research, and precision medicine have revealed that targeted manipulation of diet—through specific nutrients, caloric intake, macronutrient composition, or feeding timing—can profoundly impact metabolic health, cellular senescence, systemic inflammation, and other key drivers of aging. Therefore, dietary interventions have emerged as powerful, modifiable tools to influence the biological processes of aging, offering scalable and cost-effective strategies to extend human healthspan.

This special collection seeks to highlight cutting-edge research that elucidates how dietary strategies can be optimized to delay aging and its associated pathologies, bridging mechanistic insights from preclinical models to translational applications in humans. The editors particularly encourage submissions employing innovative methodologies—such as multi-omics integration, AI-driven dietary pattern analysis, or wearable technology for monitoring dietary adherence. By synthesizing evidence across species and study designs, this collection will advance our understanding of diet as a cornerstone of healthy aging.

The editors welcome submission of original research articles, reviews, and clinical studies that address following aspects of dietary interventions:

• Specific nutrients Interventions: role of bioactive compounds, micronutrient deficiencies or supplementation in health and diseases
• Caloric and macronutrient modulation: caloric restriction, ketogenic diets, and protein/amino-acid restriction in aging models
• Feeding timing: time-restricted eating in metabolic health and aging
• Aging clocks and biomarkers to assess the efficacy of temporal dietary interventions
• Gut microbiome-nutrient interactions in aging and disease prevention
• Sex-specific or genetic background-dependent responses to dietary macronutrient adjustments
• Organoid and in vitro systems to dissect nutrient-sensing pathways
• Clinical trials testing dietary interventions for age-related diseases
• Synergistic effects of diet with pharmacologic or lifestyle interventions (e.g., exercise)
• Epidemiological studies linking dietary patterns to health parameters or longevity hotspots
• Personalized nutrition approaches based on genomics, metabolomics, or gut microbiota profiling
• Synergistic effects of diet with pharmacologic or lifestyle interventions (e.g., exercise)